База знаний

The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia

Научные статьи
Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding
RNA (ncRNA) molecules that play a significant role in gene expression regulation. Circular RNAs
can aect microRNA functionality, interact with RNA-binding proteins (RBPs), translate proteins by
themselves, and directly or indirectly modulate gene expression during dierent cellular processes.
The aected expression of circRNAs, as well as their targets, can trigger a cascade of events in the genetic regulatory network causing pathological conditions. Recent studies have shown that altered circular RNA expression patterns could be used as biomarkers in psychiatric diseases, including schizophrenia (SZ); moreover, circular RNAs together with other cell molecules could provide new insight into mechanisms of this disorder. In this review, we focus on the role of circular RNAs in the pathogenesis of SZ and analyze their biomarker and therapeutic potential in this disorder.